|Has anyone been using the CLOtest
on dogs, particularly re-acquired hypertrophic pylori stenosis?
Not that we know of, except that we do know that the CLOtest does
detect urease in the stomach of dogs, and dogs do sometimes develop
gastric ulcers similar to humans.
|Where can I get more information
about the serological diagnosis of H. pylori?
Serologic diagnosis of H. pylori is discussed in the following
- Aucher P, Petit ML, Mannant PR, Pezennec L, Babin P, Fauchere
JL. Use of immunoblot assay to define serum antibody patterns
associated with Helicobacter pylori infection and with H. pylori-
related ulcers. Journal.of.Clinical.Microbiology. 1998; 36: 931-936.
- Chey WD, Murthy UK, Linscheer W, et al. The ChemTrak Hp Chek
fingerstick whole blood serology test for the detection of Helicobacter
pylori infection. American.Journal.of.Gastroenterology 1998; 93:
- Fallone CA, Loo VG, Barkun AN. Utility of serology in determining
Helicobacter pylori eradication after therapy. Canadian.Journal.of.Gastroenterology
1998; 12: 117224.
- Glupczynski Y. Microbiological and serological diagnostic tests
for Helicobacter pylori: an overview. [Review] [44 refs]. British.Medical.Bulletin.
1998; 54: 175286.
- Kroser JA, Faigel DO, Furth EE, Metz DC. Comparison of rapid
office-based serology with formal laboratory- based ELISA testing
for diagnosis of Helicobacter pylori gastritis. Digestive.Diseases.&.Sciences.
1998; 43: 103208.
- Laheij RJ, Witteman EM, Bloembergen P, de Koning RW, Jansen
JB, Verbeek AL. Short-term follow-up by serology of patients given
antibiotic treatment for Helicobacter pylori infection. Journal.of.Clinical.Microbiology.
1998; 36: 11932196.
|A serological test came up negative.
Should I have a breath test or should I repeat the serological test?
To be absolutely certain that you do not have H. pylori,
you may wish to repeat the serologic test at another laboratory.
The rapid serology tests done in doctors' practices are not as accurate
as the serology tests that are performed by sending the blood to
the lab. To be doubly sure you may wish to have a breath test.
|Is it possible to obtain a false
negative blood test for H. pylori and can DNA be used to detect
Yes, this may occur in 5% of persons in laboratory based tests.
DNA can be used to detect H. pylori if the specimen is gastric
juice or a gastric biopsy. DNA tests are not routine at this time.
|Are there any non-radioactive
tests for diagnosing H. pylori?
Blood tests and breath tests exist which are non-radioactive. These
test are less convenient and usually more expensive than the radioactive
test. The C14 Urea Breath Test described in these web pages is such
a low dose that it is no worse that spending an hour on an aeroplane
or 24 hours of background radiation so there is no logical reason
for concern about it.
|What is the significance of a
708.9 u/ml of a H. pylori IgG level?
Every lab may give a different normal range and abnormal range
for H. pylori. This just depends on how the test is done.
Usually the investigation report will quote what the normal range
is for that laboratory. Typically, in a H. pylori IgG test,
the patient's serum is compared with the levels in normal people
and in persons known to have H. pylori.
|Is it possible to test positive
for H. pylori after receiving one infusion of Venoglobulin
It is possible to test positive for H. pylori after receiving
gammaglobulin or blood transfusion.
|How long after eradication can
the blood be tested for H. pylori antibodies with any accuracy?
For a blood test to accurately show eradication of H. pylori
it is usual to test the antibody level at 3 and 6 months after the
infection and to show that at each time point antibodies are lower
than at the baseline (before treatment) level.