The table below was developed by the following authors

Barry J. Marshall M.D.

Loren Laine M.D

Dr. Aruni Mendis PhD, Dip.Imp.Coll.

The data was comparable with that presented at the American Gastrointestinal Association conference held in Washington D.C. in May 1997. Most data is still valid as of July 2006.

Please Note that 20mg omeprazole and 30 mg lansoprazole are equivalent in most treatments.

• Omeprazole 20 mg bid or Lansoprazole 30 mg bid
• Clarithromycin 500 mg bid
• Metronidazole 250 mg qid (or tid)
• Amoxicillin 1 g bid or Metronidazole 500 mg bid if Amoxycillin intolerant

• Bismuth subsalicylate (Pepto-Bismol) 2 (How many mg???) tablets qid in U.S.
  OR
  
• Colloidal bismuth subcitrate [De-Nol]** 120mg qid outside U.S.
  • Tetracycline 500 mg qid
  • Metronidazole 400 mg qid
  • Proton Pump Inhibitor (20mg Omeprazole bid or 30 mg lansoprazole. bid)
  
  **De-Nol is Available in Australia Under the TGA’s Special Access Scheme (SAS) Contact Tri-Med Distributors P/L; Email sales@trimed.com.au ; Ph. +61 8 9388 1444
  

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  Furazolidone & Bismuth Based (Second Line) Quadruple Therapies : Cure Rate >92%  Duration of Treatment 14 day

  
  
  • Furazolidone 200mg bid
  • Colloidal Bismuth Subcitrate (De-Nol) 120mg qid
  • Amoxicillin 1000mg bid
  • 20mg Omeprazole bid OR 30 mg lansoprazole. bid

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  Third-Line Quadruple “Salvage Therapy” ( Marshall Therapy)

  
  
  • Cprofloxacin 500mg bid
  • Rifabutin** 150mg bid
  • Omeprazole 40mg tds (six times the normal dose)
  • Amoxycillin 1000mg tds
  
  ** Rifabutin is only available through a Hospital Pharmacy

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  Other Triple Therapies - Twice-Daily RBC-Based Triple Therapy

  
  Cure rate 90% with 2 weeks treatment.
  
  • Ranitidine bismuth citrate (RBC)** 400 mg bid
  • Clarithromycin 500 mg bid
  • Amoxicillin 1 g bid (or metronidazole 500 mg bid if Amoxicillin intolerant)
  
  **RBC has been de-listed in Australlia; However, De-Nol can be substituted for RBC. De-Nol is Available in Australia Under the TGA’s Special Access Scheme (SAS) Contact Tri-Med Distributors P/L; Email:sales@trimed.com.au ; Ph. +61 8 9388 1444

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  Other US-FDA-Approved Dual Therapies

  
  Cure rate 70% at 2 weeks
  • Omeprazole 40 mg qid
  • Clarithromycin 500 mg tid
  
  Cure rate 80% at 2 weeks
  • Ranitidine bismuth citrate 400 mg bid
  • Clarithromycin 500 mg tid
  
  

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  Common Trade Names for drugs used

  Detailed drug information

  Biaxin, Klacid	clarithromycin	Abbott
  Flagyl	metronidazole	Generic
  Tritec	ranitidine bismuth citrate	Glaxo-Wellcome
  Prilosec, Losec	omeprazole	Astra/Astra-Merck
  Prevacid	lansoprazole	bbb