The Helicobacter Foundation

Proven Therapies

Dual therapies

GENERIC NAME

DOSING

DURATION

CURE RATE (%)

omeprazole

20 mg BID

28 days

70-74

clarithromycin

500 mg TID

14 days

 


GENERIC NAME

DOSING

DURATION

CURE RATE (%)

ranitidine bismuth citrate

400 mg BID

28 days

73-84

clarithromycin

500 mg TID

14 days

 


GENERIC NAME

DOSING

DURATION

CURE RATE (%)

lansoprazole

30 mg TID

14 days

66-77

amoxycillin

1,000 mg TID

14 days

 

Triple Therapies

GENERIC NAME

DOSING

DURATION

CURE RATE (%)

bismuth subsalicylate

Two tablets (525 mg) QID

14 days

77-82

or

 

 

( * see note below)

bismuth subcitrate

One tablet (120 mg) QID

14 days

 

metronidazole

250 mg QID

14 days

 

tetracycline

500 mg QID

14 days

 

H 2 antagonist

dose to heal ulcer

28 days

 


GENERIC NAME

DOSING

DURATION

CURE RATE (%)

lansoprazole

30 mg BID

14 days

86-92

amoxycillin

1,000 mg BID

14 days

 

clarithromycin

500 mg BID

14 days

 

Quadruple therapies

GENERIC NAME

DOSING

DURATION

CURE RATE (%)

bismuth subsalicylate

Two tablets (525 mg) QID

7 days

85-95

or

 

 

( * see note below)

Colloidal bismuth subcitrate

One tablet (120 mg) QID

14 days

 

metronidazole

250 mg QID

7 days

 

tetracycline

500 mg QID

7 days

 

omeprazole

20 mg BID

7 days

 

or

 

 

 

lansoprazole

30 mg BID

7 days

 


=== =Generic name=====

====DOSING========

 

===DURATION====

====CURE RATE==

Colloidal bismuth subcitrate

120mg QID

14 days

72%

Furazolidone

100mg BID ***

14 days

 

Amoxycillin

1000mg BID

14 days

 

Omeprazole

20mg BID

14 days

 

 

 

Double Furazolidone dose

 

 

 

Colloidal bismuth subcitrate

120mg QID

14 days

92%

Furazolidone

200mg BID***

14 days

 

Amoxycillin

1000mg BID

14 days

 

Omeprazole

20mg BID

14 days

 

 

 

Marshall Therapy

 

 

 

=== =Generic name=====

====DOSING========

 

===DURATION====

====CURE RATE==

Amoxycillin

1000mg BID

14 days

90-92%

Omeprazole

40mg TDS

(6 times normal dosage)

14 days

 

Ciprofloxacin

500mg BID

14 days

 

Rifabutin

150mg BID

14 days

 

 

 

 

 

 

Cammarota et.al. (2000)

 

 

Rabeprazole (R)

20mg OD

7 days

 

Levofloxacin (L)

500mg OD

7 days

RLA Cure rate=92%

Amoxycillin (A)

1000mg BID)

7 days

 

 

 

 

 

 

 

 

 

 

 

 

 

Tinidazole (T)

500mg (BID)

7 days

RLT Cure rate =90%

 

 

 

 

 

Nagahara et al. (2000)

 

 

Rabeprazole (R)

10mg BID

5 days

 

Amoxicillin (A)

750mg BID

5 days

 

Clarithromycin (C)

200mg BID

5 days

RAC Cure rate 86.7%(PP)

80% (ITT)

Metronidazole (M)

250mg BID

5 days

RACM Cure rate

98.1% (PP)

94.5% (ITT)

 

 

 

 

 

Luth et al (2001)

 

 

Rabeprazole

20mg BID

4 days

 

Clarithromycin

500mg BID

4 days

Cure Rate =90%

Amoxycillin

1000mg BID

4 days

 

 

 

 

 

 

Wong et al. 2003

 

 

Rabeprazole

20mg BID

7 days

Cure rate 91% (PP)

Rifabutin

300mg QID

7 days

Cure rate 91% (ITT)

Levofloxacin

500mg QID

7 days

 

 

 

 

 

 

Wong et al (2003)

 

 

Rabeprazole

20mg BID

7 days

 

Colloidal Bismuth Subcitrate

120mg QID

7 days

Cure rate 92% (PP)

Metronidazole

400mg TID

7 days

Curea rate 91%(ITT)

Tetracycline

500mg QID

7 days

 

 

 

 

 

 

Therapies Under Evaluation

GENERIC NAME

DOSING

DURATION

CURE RATE (%)

omeprazole

20 mg BID

10-14 days

85-95

or

 

 

( * see note below)

lansoprazole

30 mg BID

10-14 days

 

clarithromycin

500 mg BID

10-14 days

 

metronidazole

500 mg BID

10-14 days

 

*Note: In some countries they have found that 7 days therapy with this regimen is equally effective.

GENERIC NAME

DOSING

DURATION

CURE RATE (%)

omeprazole

20 mg BID

10-14 days

85-95

or

 

 

 

lansoprazole

30 mg BID

10-14 days

 

clarithromycin

500 mg BID

10-14 days

 

amoxycillin

1,000 mg BID

10-14 days

 


GENERIC NAME

DOSING

DURATION

CURE RATE (%)

rantidine bismuth citrate

400 mg BID

10-14 days

80-95

clarithromycin

500 mg BID

10-14 days

 

amoxycillin

1,000 mg BID

10-14 days

 


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